Arsenal have lost just one of their 11 knockout clashes with Spanish opponents on home soil (W7 D3), with that sole defeat coming in February 2016 against Barcelona in the Champions League Last 16 (0-2).
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Villarreal’s Gerard Moreno has either scored or assisted in each of his seven starts in the UEFA Europa League this season (6 goals, 3 assists), with only one player providing goal involvements in more consecutive starts in a single season in the competition since 2009-10 (Willian - 9 with Chelsea in 18-19).
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AS Roma Vs Manchester United
Manchester United thrashed AS Roma 6-2 in the first leg of their Europa League semi-final tie at Old Trafford, but Ole Gunnar Solskjaer’s side must now put the turbulent events of the past week out of their minds and focus on reaching the final.
It was only the fourth time Roma have conceded six or more goals in a match in major European competition, with two coming against United following the 7-1 defeat in April 2007.
The visitors head into the second leg having had a full week of rest following the postponement of their Premier League encounter with Manchester United at Old Trafford last Sunday as a result of the anti-Glazer demonstration.
United are looking to progress to their first major final in any competition under Solskjaer having previously been knocked out of all four cup semi-finals under the Norwegian.
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Team News
Roma goalkeeper Pau Lopez misses out after dislocating his shoulder in the first leg with Daniel Furzato and Antonio Mirante competing for the position.
Fonseca made seven changes for the weekend defeat to Sampdoria in Serie A, with Leonardo Spinazzola, Jordan Veretout and Amadou Diawara all injured.
Defender Gianluca Mancini is available after suspension and former United defender Chris Smalling and Henrikh Mkhitaryan will hope to be in the starting line-up again.
Daniel James has not travelled with the Manchester United squad due to injury. The 23-year-old was absent from the squad named for Sunday’s ultimately postponed Premier League clash against Liverpool.
James joins Anthony Martial and Phil Jones on the sidelines, with Amad Diallo and Anthony Elanga named as part of the 24-man squad heading to Italy.
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Possible Starting Lineup
Roma possible starting lineup:
Mirante; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Villar, Peres; Pellegrini, Mkhitaryan; Dzeko
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Rashford, Fernandes, Pogba; Greenwood
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In the history of the UEFA Cup/Europa League, of the 225 previous instances of a team losing the first leg of a two-legged knockout tie by 4+ goals, just two have progressed; FK Partizan v QPR in the 1984-85 last 32 and Real Madrid v Borussia Monchengladbach in the 1985-86 last 16.
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Manchester United have won five of their last six meetings with Roma in all competitions, drawing the other 1-1 in December 2007.
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Manchester United have won each of their last four UEFA Europa League games, last winning five successive matches in all European competition in May 2011, before losing to Barcelona in the UEFA Champions League final at Wembley.
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1st Leg Result
Crunch time for the Gunners in Europa League semi-final second leg. Can they find a comeback victory? 
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1st Leg Result
How will this Europa League semi-final play out tonight?
Roma need a miracle comeback to progress to the final. 
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Manchester United vs Roma Line Up
Roma XI: Mirante; Karsdorp, Smalling, Ibañez, Bruno Peres; Cristante, Mancini; Pedro, Pellegrini, Mkhitaryan; Džeko.
Man Utd XI: De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; Van de Beek, Fred; Greenwood, Fernandes, Pogba; Cavani.
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Only five players have made 100+ appearances for Man Utd before turning 20 years old:
Norman Whiteside
George Best
Ryan Giggs
Duncan Edwards
Mason Greenwood 
Following in some famous footsteps.
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OFFICIAL: Kieran Tierney has replaced Granit Xhaka in the Arsenal XI due to an injury in the warm-up.
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Villarreal’s Samuel Chukwueze is forced off injured and replaced by 18-year-old Yeremi Pino.
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Roma are also forced into an early change as Chris Smalling can’t continue.
Ebrima Darboe replaces him.
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Edinson Cavani puts Man Utd ahead against Roma.
They now lead 7-2 on aggregate.
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Edinson Cavani has been directly involved in five of Man Utd’s seven goals over the two legs against Roma:
3 goals
2 assists
And he won a penalty in the first leg. 
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